张容容
职称/职位:副研究员
学位:博士
学院:中药学院(国际中医药转化医学研究所)
E-mail: zrr586@gzucm.edu.cn
办公电话:020-39358651
办公室:广州大学城广州中医药大学针灸楼214室
教育及工作经历:
教育经历:
2015/10-2016/10,英国兰卡斯特大学,生物化学,联合培养博士,导师:David A. Middleton
2012/09-2016/12,暨南大学,药学院,博士;导师:江仁望
2010/09-2012/06,暨南大学,药学院,硕士;导师:江仁望
2005/09-2009/06,山西中医药大学,药学院,学士
工作经历:
2017/04-至今, 广州中医药大学,国际中医药转化医学研究所,副研究员
研究领域及方向:
科研领域:中药及天然药物化学
研究方向:天然产物的分离,鉴定及其生物活性研究。
学术成果:
科研项目
(1)国家自然科学基金青年科学基金项目,81703814,断节参中C21甾苷类成分的分离鉴定及其肿瘤耐药逆转活性研究,2018/01-2020/12,20万元,主持,在研。
(2)广州市科技计划项目一般科学研究,2018-1002-SF-0474,八角瓜乳汁中强心苷类成分的分离鉴定及其强心作用机制研究,2018/04-2021/03,20万元,主持,在研。
(3)广州中医药大学2017年度“高水平大学建设”“杏林后备人才”项目, A1-AFD018171Z0317,A1-AFD018161Z0140, 2017/04-2020/03,50万元,在研,主持。
近年来发表的论文:
(1) Rongrong Zhang#, Zexin Lin#, Xinyi Lu#, Xue Xia, Renwang Jiang*, Qubo Chen*.CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolaminetreated mice. Biomedicine & Pharmacotherapy. 2019,111, 496-502.
(2) Rongrong Zhang, Haiyan Tian, Yafang Tan, Tse-Yu Chung, Xiaohui Sun, Xue Xia, Wencai Ye, David A. Middleton, Natalya Fedosova, Mikael Esmann, Jason T. C. Tzen, Renwang Jiang*. Structures, chemotaxonomic significance, cytotoxic and Na+,K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. Organic & Biomolecular Chemistry. 2014, 12(44), 8919-8929.
(3) Rongrong Zhang#, Haiyan Tian#, Yi Wu, Jianlong Zhang, Zhiguo Ma*, Renwang Jiang*. Isolation and chemotaxonomic significance of stenine- and stemoninine-type alkaloids from the roots of Stemona tuberosa. Chinese Chemical Letters. 2014, 25(9): 1252-1255.
(4) Rongrong Zhang, Danyi Lu, Zhenya Yang, Wen Zhao, Pangchui Shaw, Renwang Jiang*, Zhiguo Ma*. Simultaneous quantification of six alkaloid components from commercial Stemonae Radix by SPE-HPLC-ELSD. Phramacognosy magazine. 2015, 11(42), 360-367.
(5) Weiqi Yuan#, Rongrong Zhang#, Wang Jun, Ma Yan, Wenxue Li, Renwang Jiang*, Shaohui Cai*. Asclepiasterol, a novel C21 steroidal glycoside derived from Asclepias curassavica, reverses tumor multidrug resistance by down-regulating P-glycoprotein expression. Oncotarget, 2016, 7(21): 31466-31483.
(6) Enpan Mo#, Rongrong Zhang#, Jun Xu#, Huan Zhang, Xiaoxiong Wang, Qiutong Tan, Fanglan Liu, Renwang Jiang*, Shaohui Cai*. Calotropin from Asclepias curasavica induces cell cycle arrest and apoptosis in cisplatin-resistant lung cancer cells. Biochemical and Biophysical Research Communications, 2016, 478(2): 710-715.
(7) Jiawen Shou#, Rongrong Zhang#, Hoiyan Wu#, Xue Xia, Hong Nie, Renwang Jiang*, Pangchui Shaw*. Isolation of novel biflavonoids from Cardiocrinum giganteum seeds and characterization of their antitussive activities. Journal of Ethnopharmacology. 2018, 222, 171-176.
(8) Rongrong Zhang, Zhiguo Ma, Guoqiang Li, Paul Puihay But, Renwang Jiang*. Tuberostemoamide hemihydrate. Acta Crystallographica, Section E: Structure Reports Online. 2011, 67(11), o3056.
授权发明专利:
(1) 江仁望,张容容,谭亚芳,田海妍,朱自荣,一种富含强心苷的马利筋乳汁提取物及其制备方法与应用,2017.11.07,中国 CN 104523792 B
(2) 江仁望,蔡绍辉,李文学,袁玮琪,张容容,C21甾Asclepiasterol及其制备方法与其在制备肿瘤多药耐药逆转剂中的应用,2017.07.04,中国CN 105669817 B