朱丽君
职称/职位：副研究员，硕士生导师。
学位：博士
学院：中药学院（国际中医药转化医学研究所）
个人获得荣誉：主要研究领域为中药药代动力学、药物吸收和代谢及其调控机制。现主持国家自然科学基金面上项目和青年项目各1项。2017年入选广州市“珠江科技新星”人才项目。完成中国博士后基金1项，广东省自然科学基金博士启动项目1项。参编英文专著1部。在Drug Metabolism & Disposition、Pharmaceutical Research、Molecular Pharmaceutics等期刊上发表SCI论文37篇。主讲《生物药剂学与药物动力学》。
教育经历
2009/09-2012/06，南方医科大学，药学院，博士
2005/09-2008/06，中山大学，附属第一医院，硕士
2001/09-2005/06，湖南中医药大学，药学院，学士
科研与学术工作经历
2015/12-至今， 广州中医药大学，中药学院（国际中医药转化医学研究所），副研究员
2014/06-2015/11，广州中医药大学，中药学院（国际中医药转化医学研究所），讲师
2015/05-2015/10，美国休斯敦大学，药学院，访问学者
2012/07-2014/05，广州医科大学，药学院，博士后
研究方向
中药药代动力学、药物吸收和代谢及其调控机制
科研课题
[1] 国家自然科学基金面上项目，81874343，基于“化学-PD/PK”的附子质量标志物发现、确证及其调控毒效的分子机制研究，2019/01-2022/12，57万元，在研，主持
[2] 广州市科技计划项目珠江科技新星专题，201806010199，基于UGT代谢酶和外排转运蛋白偶联作用的秦皮香豆素类活性成分及其衍生物体内处置特征及机理研究，2018/04-2021/03，30万元，主持
[3] 国家科技重大专项，2017ZX09301051，组分结构中药新品种奥斯替宝研发及其关键创新技术，2017/01-2020/12，70万元，子课题负责人
[4] 国家自然科学基金青年项目，81603379，中药秦皮及其香豆素类活性成分的肝肠处置及调控机制，2017/01-2019/12，17万元，在研，主持
[5] 广州中医药大学2017年度“高水平大学建设”青年项目A1-AFD018171Z11051，外排转运蛋白和CYP酶调控附子中乌头生物碱毒性和药效的作用及分子机制，2017/01-2018/06，10万元，在研，主持
[6] 广东省自然科学基金博士科研启动项目，2014A030310417，外排转运蛋白和CYP酶阻抗附子中乌头生物碱毒性的作用及分子机制，2014/10-2017/10，10万元，结题，主持
[7] 中国博士后科学基金，2013M542166，α1D-AR拮抗剂YM03对映异构体和外消旋体吸收代谢研究，2013/06-2014/06，5万元，已结题，主持
承担课程
主讲《生物药剂学与药物动力学》
代表性研究论文
1 Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu*, and Lijun Zhu*. Breast cancer resistance protein and multidrug resistance protein 2 determine the disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Pharmaceutical Research.47:203-214, 2019.
2 Yuhuan Li, Linlin Lu, Liping Wang, Wei Qu, Wenqin Liu, Yushan Xie, Hongming Zheng, Ying Wang, Xiaoxiao Qi, Ming Hu*, Lijun Zhu*, and Zhongqiu Liu*. Interplay of efflux transporters with glucuronidation and its impact on subcellular aglycone and glucuronide disposition: a case study with kaempferol. Molecular Pharmaceutics.15:5602-5614, 2018.
3 Haihui Zheng, Liping Wang, Sijing Zeng, Jiamei Chen, Haojia Wang, Jia Yu, Xia Gong, Huangyu Jiang, Xia Yang, Xiaoxiao Qi, Ying Wang, Linlin Lu, Ming Hu*, Lijun Zhu*, and Zhongqiu Liu*. Age-related changes in hepatic expression and activity of drug metabolizing enzymes in male wild-type and breast cancer resistance protein knockout mice. Biopharmaceutics & drug disposition. 39(7):344-353, 2018.
4 Jiamei Chen, Qisong Zhang, Xiaoyan Li, Xia Gong, Yanjiao Ruan, Sijing Zeng, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu*, Lijun Zhu*, and Zhongqiu Liu*. Tissue distribution and gender-specific protein expression of cytochrome P450 in five mouse genotypes with a background of FVB. Pharmaceutical Research. 35:114, 2018.
5 Lijun Zhu, Jinjun Wu, Min Zhao, Wenjie Song, Xiaoxiao Qi, Ying Wang, Linlin Lu*, and Zhongqiu Liu*. Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics. Toxicology and Applied Pharmacology. 320:32-39, 2017.
6 Shun Feng#, Lijun Zhu#, Zhisheng Huang, Haojia Wang, Hong Li, Hua Zhou, Linlin Lu, Ying Wang, Zhongqiu Liu*, and Liang Liu*.Controlled release of optimized electroporation enhances the transdermalefficiency of sinomenin hydrochloride for treating arthritis in vitro and in clinic. Drug Design, Development and Therapy. 11:1737-1752, 2017.
7 Huangyu Jiang, Jia Yu, Haihui Zheng, Jiamei Chen, Jinjun Wu, Xiaoxiao Qi, Ying Wang, Xinchun Wang, Ming Hu, Lijun Zhu*, and Zhongqiu Liu*. Breast cancer resistance protein and multidrug resistance protein 2 regulate the disposition of acacetin glucuronides. Pharmaceutical Research. 34(7):1402-1415, 2017.
8 Jia Yu#, Lijun Zhu#, Haihui Zheng, Xia Gong, Huangyu Jiang, Jiamei Chen, Yuhuan Li, Hongming Zheng, Xiaoxiao Qi, Ying Wang, Ming Hu , Linlin Lu*, and Zhongqiu Liu*. Sulfotransferases and breast cancer resistance protein determine the disposition of calycosin in vitro and in vivo. Molecular Pharmaceutics. 14(9):2917-2929, 2017.
9 Jiamei Chen#, Lijun Zhu#, Xiaoyan Li, Haihui Zheng, Tongmeng Yan, Cong Xie, Sijing Zeng, Jia Yu, Huangyu Jiang, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, and Zhongqiu Liu*. High throughput and reliable isotope label-free approach for profiling 24 metabolic enzymes in FVB mice and gender differences. Drug Metabolism and Disposition. 45(6):624-634, 2017.
10 Jiamei Chen, Haihui Zheng, Sijing Zeng, Cong Xie, Xiaoyan Li, Tongmeng Yan, Xia Gong, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu*, and Zhongqiu Liu *. Profiles and gender-specific ofUDP-glucuronosyltransferases and sulfotransferases expressions in the major metabolic organs of wild-type and efflux transporter knockout FVB mice. Molecular Pharmceutics. 9(14):2967-2976, 2017.
11 Liang Zheng#, Lijun Zhu#, Min Zhao, Jian Shi, Yuhuan Li, Jia Yu, Huangyu Jiang, Jinjun Wu, Yunli Tong, Yuting Liu, Ming Hu, Linlin Lu, and Zhongqiu Liu. In vivo exposure of kaempferol is driven by phase Ⅱ metabolic enzymes and efflux transporters. The AAPS Journal. 18(5):1289-99, 2016.
12 Lijun Zhu#, Linlin Lu#, Shan Zeng, Feifei Luo, Peimin Dai, Peng Wu, Ying Wang, Liang Liu, Ming Hu, and Zhongqiu Liu*. UDP-Glucuronosyltransferases 1A6 and 1A9 are the major isozymes responsible for the 7-O-glucuronidation of esculetin and 4-methylesculetin in human liver microsomes. Drug Metabolism and Disposition. 43(7):977-83, 2015.
13 Peimin Dai#, Lijun Zhu#, Xiaoshan Yang, Min Zhao, Jian Shi, Ying Wang, Linlin Lu*, and Zhongqiu Liu*. Multidrug resistance-associated protein 2 is involved in the efflux of aconitum alkaloids determined by MRP2-MDCKII Cells. Life Sciences. 127(2015):66-72, 2015.
14 Lijun Zhu#, Xiawen Liu#, Liu Zhu, Xingfei Zhang, Xiaojing Fu, Junjun Huang, and Mu Yuan*. Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. Journal of Pharmacy and Pharmacology. 66(11):1534-51, 2014.
15 Lijun Zhu, Linlin Lu, Enshuang Guo, Jinjun Wu, Ying Wang, Ming Hu, and Zhongqiu Liu*. The influence of aconitine, an active/toxic alkaloid from Aconitum, on the pharmacokinetic of CYP3A probe drug buspirone in rats. Drug Metabolism Letters. 8(2):135-144, 2014.
16 Peimin Dai#, Lijun Zhu#, Feifei Luo, Linlin Lu, Qiang Li, Liping Wang, Ying Wang, Xinchun Wang, Ming Hu*, and Zhongqiu Liu*. Triple recycling processes impact systemic and local bioavailability of orally administered flavonoids. The AAPS Journal. 17(3):723-36, 2014.
一 专著
1 Lijun Zhu, Linlin Lu, Stephen Wang, Jinjun Wu, Jian Shi, Tongmeng Yan, Cong Xie, Qiang Li, Ming Hu and Zhongqiu Liu, Chapter 11— Oral Absorption Basics: Pathways and Physicochemical and Biological Factors Affecting Absorption, in “Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice” (Edited by Qiu YH, Chen YS, Zhang G, Yu L, and Mantri RV), 2nd Edition, Publisher: Mica Haley, Pages: 297-329, Page Count1176, eBookISBN: 9780128026373, Hard cover ISBN：9780128024478, Imprint: Academic Press, 11.28, 2016. http://doi.org/10.1016/B978-0-12-802447-8.00042-X
