林娜

职称/职位：研究员；中国中医科学院首席研究员，正高二级，博士生导师。现任中国中医科学院中药研究所中药理论与本草文献研究中心主任，国家中医药管理局临床中药学重点学科带头人，国家药典委员会委员，享受国务院政府特殊津贴专家。

学位：博士

E-mail: linna888@163.com

个人获得荣誉：先后获得国务院政府特殊津贴专家、中华中医药学会科学技术进步一等奖、中国中西医结合学会科学技术成果一等奖奖、中华中医药学会李时珍医药创新奖等。

教育、工作经历：

教育经历：

2009.07 中国中医科学院，博士后出站

2005.05 日本东京药科大学，药学博士学位

2000.06 日本东京药科大学，访问学者

1985.07 广州中医药大学, 医学学士学位

工作经历：

2016.10~至今    中国中医科学院首席研究员

2013.01~至今    中国中医科学院中药研究所中药理论与本草文献研究中心, 执行主任

2012.09~至今    国家中医药管理局, 重点学科带头人

2009.12~至今    中国中医科学院, 学科带头人

2007.03~2010.02  国家自然科学基金委生命科学/医学科学部, 中药项目主任

2005.10 ~2013    中国中医科学院中药研究所中药药性理论与复杂性科学研究室, 主任

1999.07~2000.06  日本东京药科大学, 访问学者

1985.07~2003     中国中医科学院中药研究所, 实习研究员~研究员

研究领域及方向：

科研领域：中药药理学

科学科目：中药药理学

研究方向：1）抗炎免疫中药药理

2）经典名方的科学内涵

3）中药药性的表征及科学内涵

4）中药合理用药

承担课程：中药药理，中药药性

代表性科研及教学课题：

1)      2017.01-2021.12：基于病-证-方关联分子网络的寒/热痹病经方抗类风湿性关节炎生物学内涵研究（国家自然科学基金重点项目）

2)      2017.01-2020.12青蒿素及其衍生物创新药物研究—双氢青蒿素治疗神经病理性疼痛的临床前研究及抗炎免疫药效评价关键技术构建（科技部重大新药创制）

3)      2014.01-2015.12：基于中医临床转化的中药创新品种研发（科技部重大新药创制）

4)      2011.01-2015.12：基于妨害治疗的中药“十八反”配伍基础研究（973计划）

5)      2011.01-2013.12：中药五类新药地乌风湿安胶囊治疗类风湿性关节炎的研究（科技部重大新药创制）

代表性成绩：

1）科学研究：

作为课题负责人承担/完成973计划（子课题）、国家重大新药创制专项和国家自然科学基金重点项目等国家课题20多项，获中国中西医结合学会和中华中医药学会科技进步一等奖等科研成果12项（7项署名第一），在The Lancet、Arthritis Rheum、Biochem Pharmacol、Cell Death and Disease、RNA Biol和Mol Neurobiol和药学学报等国内外知名刊物发表学术论文约200篇，出版学术专著13部，获得国家发明专利授权12项，发布行业指南/共识4个。先后培养博士、硕士和博士后52名，其中获国家奖学金和优秀毕业生、优秀学位论文奖17人次。

2）学术兼职：

国家药典委员会委员、中国中药协会骨伤科药物研究专业委员会主任委员、中华中医药学会免疫分会和世界中医药联合会临床用药安全研究分会副会长等，曾任国家自然科学基金委生命科学部中西结合学流动项目主任和医学科学部中药学流动项目主任。

3）学术交流：

参加国内外重要学术会议并受邀做主旨报告，同时也主办大型全国学术会议。

近三年代表性文章：

 

1)  Li T, Zhang Y, Wang R, Xue Z, Li S, Cao Y, Liu D, Niu Y, Mao X, Wang X, Li W, Guo Q, Guo M, Lin N, Chen W. Discovery and validation an eight-biomarker serum gene signature for the diagnosis of steroid-induced osteonecrosis of the femoral head. Bone. 2019 Mar 8;122:199-208. doi: 10.1016 /j.bone. 2019.03.008. [Epub ahead of print].

2)      Zhang YQ, Shen Y, Liao MM, Mao X, Mi GJ, You C, Guo QY, Li WJ, Wang XY, Lin N, Webster TJ. Galactosylated chitosan Triptolide nanoparticles for overcoming hepatocellular carcinoma: Enhanced therapeutic efficacy, low toxicity, and validated network regulatory mechanisms. Nanomedicine: Nanotechnology, Biology and Medicine. Available online 19 September 2018. https://doi.org/10.1016/j.nano.2018.09.002

3)      Zhang Y, Jiang F, He H, Ye J, Mao X, Guo Q, Wu SL, Zhong W, Wu CL, Lin N. Identification of a novel microRNA-mRNA regulatory biomodule in human prostate cancer. Cell Death Dis. 2018 Feb 21;9(3):301. doi: 10.1038/s41419-018-0293-7.

4)      Zhang Y, Wang H, Mao X, Guo Q, Li W, Wang X, Li G, Lin N. A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients. J Transl Med. 2018 Jul 4;16(1):187. doi: 10.1186/s12967-018-1549-9.

5)      Zhu C, Xu Q, Mao Z, Lin N. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Sci Rep. 2018 Aug 16;8(1):12292. doi: 10.1038/s41598-018-30006-7.

6)      Zhang Y, Wang H, Mao X, Guo Q, Li W, Wang X, Li G, Jiang Q, Lin N. A Novel Circulating miRNA-Based Model Predicts the Response to Tripterysium Glycosides Tablets: Moving Toward Model-Based Precision Medicine in Rheumatoid Arthritis. Front Pharmacol. 2018 May 24;9:378. doi: 10.3389/fphar.2018.00378.

7)      Zhang YQ, Wang C, Guo QY, Zhu CY, Yan C, Sun DN, Xu QH, Lin N. Molecular mechanisms of the analgesic action of Wu-tou Decoction on neuropathic pain in mice revealed using microarray and network analysis, Acta Pharmacol Sin, 2018 39(6): 988-997.

8)      Xu Y, Chen T, Li X, Ya Kun Q, An JN, Zheng HX, Zhao Y, Zhang ZJ, Lin N. Veratrum nigrum inhibits the estrogenic activity of salvia miltiorrhiza bunge in vivo and in vitro. Phytomedicine. 2018 Apr 1;43:68-77. doi: 10.1016/j.phymed.2018.03.038.

9)      Zhang YQ，Wang C, Guo QY, Zhu CY, Yan C, Sun DN, Xu QH, Lin N. Molecular mechanisms of the analgesic action of Wu-tou Decoction on neuropathic pain in mice revealed using microarray and network analysis. Acta Pharmacol Sin. 2018 Jun;39(6):988-997.

10) Xu Y, Li X, Chen T, Qu YK, Zheng HX, Zhang ZJ, Zhao Y, Lin N. Radix Paeoniae Alba increases serum estrogen  evel and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Phytother Res. 2018 Oct 29. doi: 10.1002/ptr.6205.

11) He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N. Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling. Rejuvenation Res, 2018. 21(5):442-455.

12) Wang C, Kong X, Zhu C, Liu C, Sun D, Xu Q, Mao Z, Qin Q, Su H, Wang D, Zhao X, Lin N. Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling, Oncotarget, 2017, 8(54): 92864-92879.

13) Zhang Y, Yan C, Li Y, Mao X, Tao W, Tang Y, Lin Y, Guo Q, Duan J, Lin N. Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis. Sci Rep. 2017;7:41925.

14) Kong X, Li X, Zhang C, Zhu L, Liu C, Qin Q, Liu C, Wang Q, Zhu J, Wu X, Wan H, Chen W, Lin N. Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways. Int. J. Biol. Sci. 2017; 13(4): 480-491.

15) Liu C, Su H, Wan H, Qin Q, Wu X, Kong X, Lin N. Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function. Int J Biol Sci. 2017;13(1):65-75.

16) Zhu C, Xu Q, Wang C, Mao Z, Lin N. Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain, Sci Rep, 2017, 7(1): 11935.

17) Kong X, Zhong M, Su X, Qin Q, Su H, Wan H, Liu C, Wu J, Shang H, Zhang Y, Lin N. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2016;53(9):6526-6539.

18) Xu Y, Ding J, An JN, Qu YK, Li X, Ma XP, Zhang YM, Dai GJ, Lin N. Effect of the Interaction of Veratrum Nigrum with Panax Ginseng on Estrogenic Activity In Vivo and In Vitro. Sci Rep. 2016 May 27;6:26924. doi: 10.1038/srep26924.

19) Zhang Y, Mao X, Guo Q, Bai M, Zhang B, Liu C, Sun Y, Li S, Lin N. Pathway of PPAR-gamma coactivators in thermogenesis: a pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis. Oncotarget. 2016 Mar 29;7(13):15885-900.

20) Zhang Y, Li Y, Mao X, Yan C, Guo X, Guo Q, Liu Z, Song Z, Lin N. Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter. Oncotarget. 2016 Aug 9;7(32):51699-51712.

21) Xu Y, Chen T, Li X, Qu YK, An JN, Zheng HX, Zhang ZJ, Lin N. Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice. Aging (Albany NY). 2016 Dec 20;9(1):156-172. doi: 10.18632/aging.101145.

22) Guo Q, Mao X, Zhang Y, Meng S, Xi Y, Ding Y, Zhang X, Dai Y, Liu X, Wang C, Li Y, Lin N. Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance, J Transl Med, 2016, 14(1): 165.

23) Kong X, Li X, Zhang C, Zhu L, Wan H, Zhu J, Liu C, Su H, Qin Q, Chen W, Lin N. Aqueous Fraction of Huogu Formula Promotes Osteogenic Differentiation of Bone Marrow Stromal Cells Through the BMP and Wnt Signaling Pathways. Rejuvenation Res. 2016;19(6):509-520.

24) Xu Y, Ma X, An J, Ding J, Dai G, Liu Z, Song Z, Lin N. Treatment with QiBaoMeiRan, a Chinese herbal formula, prevents bone loss in ovariectomized rat. Climacteric. 2016;19(1):98-106. doi: 10.3109/13697137.2015.1053861.