王 莹
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职称/职位：技术员 学院:中药学院（国际中医药转化医学研究所） E-mail: wangy@gzucm.edu.cn 办公电话：020-39358071 办公室：广州大学城广州中医药大学针灸楼216室
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简介
王莹，中药学院（国际中医药转化医学研究所）技术员。2015年毕业于南方医科大学获医学硕士学位，2015年4月-10月前往美国罗格斯新泽西州立大学做交换培养，主要学习表观遗传学对结直肠癌发病机制的影响。参讲《药物毒理学》、《生物药剂学与药物动力学》实验课程。近三年参研国家自然科学基金2项，省级科研项目5项。以共同一作身份发表SCI论文1篇，影响因子4.480，参与发表SCI论文10余篇，参与申请中国发明专利11项。
学历
2015/04-2015/10，美国罗格斯新泽西州立大学，药学院，交换研究生，导师：Ah-Ng Tony Kong
2012/09-2015/06，南方医科大学，药学院，硕士，导师：刘中秋
2007/09-2011/06，南方医科大学，药学院，学士
学术成果
代表性文章
(1) Linlin Lu#, Ying Wang#, Rilan Ou, Qian Feng, Liyan Ji, Hongming Zheng, Yue Guo, Xiaoxiao Qi, Ah-Ng Tony Kong*, Zhongqiu Liu*, DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment, Pharmacological Research, 2018, 129:318-328
(2) Shidong Lv#, Liyan Ji#, Bin Chen, Shuqiang Liu, Chengyong Lei, Xi Liu, Xiaoxiao Qi, Ying Wang, Elaine Lai-Han Leung, Hongyi Wang, Lin Zhang, Xiaoming Yu, Zhongqiu Liu*, Qiang Wei*, Linlin Lu*, Histone Methyltransferase KMT2D Sustains Prostate Carcinogenesis and Metastasis Via Epigenetically Activating LIFR and KLF4, Oncogene, 2017, Dec 22. doi: 10.1038/s41388-017-0026-x
(3) Jiamei Chen#, Lijun Zhu#, Xiaoyan Li, Haihui Zheng, Tongmeng Yan, Cong Xie, Sijing Zeng, Jia Yu, Huangyu Jiang, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Zhongqiu Liu*, High Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences, Drug Metabolism and Disposition, 2017, 45 (6) 624-634
(4) Lijun Zhu, Jinjun Wu, Min Zhao, Wenjie Song, Xiaoxiao Qi, Ying Wang, Linlin Lu, Zhongqiu Liu*, Mdr1a Plays a Crucial Role in Regulating the Analgesic Effect and Toxicity of Aconitine by Altering its Pharmacokinetic Characteristics, Toxicology and Applied Pharmacology, 2017, 320: 32-39
(5) Zhiying Huang, Qiuju Huang, Liyan Ji, Ying Wang, Xiaoxiao Qi, Liang Liu, Zhongqiu Liu*, Linlin Lu*, Epigenetic Regulation of Active Chinese Herbal Components for Cancer Prevention and Treatment: A follow-up Review, Pharmacological Research, 2016, 114:1-12
(6) Wenqin Liu#, Jian Shi#, Lijun Zhu, Lingna Dong, Feifei Luo, Min Zhao, Ying Wang, Ming Hu, Linlin Lu*, Zhongqiu Liu*, Reductive Metabolism of Oxymatrine is Catalyzed by Microsomal CYP3A4, Drug Design, Development and Therapy, 2015, 9: 5771–5783.
(7) Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu, Zhongqiu Liu*, SGLT-1 Transport and Deglycosylation Inside Intestinal Cells are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats, Drug Metabolism and Disposition, 2016, 44(3):283-296
(8) Tongmeng Yan#, Linlin Lu#, Cong Xie, Jiamei Chen, Xiaojuan Peng, Lijun Zhu, Ying Wang, Qiang Li, Jian Shi, Fuyuan Zhou, Ming Hu*, Zhongqiu Liu*. Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients. Molecular Cancer Therapeutics. 2015, 14(12):2874-2886
(9) Peimin Dai, Feifei Luo, Ying Wang, Huangyu Jiang, Liping Wang, Guiyu Zhang, Lijun Zhu, Ming Hu, Xinchun Wang, Linlin Lu, Zhongqiu Liu*, Species- and Gender-Dependent Differences in the Glucuronidation of a Flavonoid Glucoside and its Aglycone Determined Using Expressed UGT Enzymes and Microsomes, Biopharmaceutics & Drug Disposition, 2015, 36(9):622-635
(10) Peimin Dai, Ying Wang, Ling Ye, Shan Zeng, Zhijie Zheng, Qiang Li, Linliu Lu, Zhongqiu Liu*, Pharmacokinetic Comparisons of Benzoylmesaconine in Rats Using Ultra-performance Liquid Chromatography-tandem Mass Spectrometry After Administration of Pure Benzoylmesaconine and Wutou Decoction, Molecules, 2014, 19(10): 16757-16769.
参研课题
[1] 国家自然科学基金面上项目，山奈酚的核内处置调控DNA甲基化酶抑制结肠癌分子机制及对中药山奈药效的影响，项目编号： 81874367， 2019/01-2022/12，59万元，参研；
[2] 国家自然科学基金青年科学基金项目，核受体介导的CYP3A4和外排转运蛋白在附子个体化用药中的作用及机制，项目编号： 81503466，2016/01/01-2018/12/31，21.6万元，参研；
[3] 广东省杰出青年科学基金项目，中药个体精准用药的药代动力学基础，项目编号：2017A030306033，2017/05/01 - 2021/05/01，100万元，参研；
[4] 广东省教育厅制广东省普通高校特色创新项目，中药精准个体化用药的药代动力学调控机制，项目编号：2016KTSCX012，2017/01/01-2018/12/31，10万元，参研；
[5] 广州中医药大学2017年度“高水平大学建设”面上项目，中药个体精准用药的药代动力学基础，2017/01-2018/06，20万元，参研。
