中药及天然药物化学研究组介绍
聚焦岭南特色药用植物,综合应用现代色谱、光谱技术,辅以现代活性筛选技术,分离、鉴定和发现活性新成分,运用现代药理研究手段,围绕“南药”重点开展中药抗肿瘤、心脑血管疾病、代谢性疾病的作用环节、作用靶标及作用机理研究,揭示中药药效物质基础,为新药研究提供活性先导化合物。
研究方向示意图
硕士生导师2名:
张容容 副研究员 吴鹏 助理研究员
(zrr586@gzucm.edu.cn) (wupeng@gzucm.edu.cn)
在读研究生8名:
研究内容一:毛冬青中三萜皂苷及其抗炎活性研究
研究内容二:马利筋中强心苷类化合物及其抗肿瘤活性研究
正在承担的项目:
1. 国家自然科学基金青年科学基金项目,81503224,岭南中药毛冬青萜类成分分离鉴定与成药性机理,2016/01-2018/12,21.6万元,主持,已结题。
2. 国家自然科学基金青年科学基金项目,81703814,断节参中C21甾苷类成分的分离鉴定及其肿瘤耐药逆转活性研究,2018/01-2020/12,20万元,主持,在研。
3. 广州市科技计划项目一般科学研究,2018-1002-SF-0474,八角瓜乳汁中强心苷类成分的分离鉴定及其强心作用机制研究,2018/04-2021/03,20万元,主持,在研。
近年发表的部分论文:
1. Rongrong Zhang, Zexin Lin, Xinyi Lu, Xue Xia, Renwang Jiang*, Qubo Chen*.CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolaminetreated mice. Biomedicine & Pharmacotherapy. 2019,111, 496-502.
2. Xiaoxu Qiao, Mengying Ji, Yunda Yao, Leilei Ma, Jinjun Wu, Guochao Liao, Hua Zhou, Zhongqiu Liu, Peng Wu*, Pubescenosides E–K, seven new triterpenoid saponins from the roots of Ilex pubescens and their anti-inflammatory activity, molecules, 2018, 23, 1426.
3. Jiawen Shou#, Rongrong Zhang#, Hoiyan Wu#, Xue Xia, Hong Nie, Renwang Jiang*, Pangchui Shaw*. Isolation of novel biflavonoids from Cardiocrinum giganteum seeds and characterization of their antitussive activities. Journal of Ethnopharmacology. 2018, 222, 171-176.
4. Shugui He, RilanOu, Wensheng Wang, Liyan Ji, Hui Gao, Yuanfeng Zhu, Xiaoming Liu, Hongming Zheng, Zhongqiu Liu, Peng Wu*, Linlin Lu*, Camptosorus sibiricus Rupr Aqueous Extract Prevents Lung Tumorigenesis via Dual Effects against ROS and DNA Damage, Journal of Ethnopharmacology, 2017, 220: 44-56.
5. Peng Wu, Hui Gao, Jianxin Liu, Liang Liu, Hua Zhou*, Zhongqiu Liu*, Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots, Phytochemistry, 2017, 134: 122-132.
6. Enpan Mo#, Rongrong Zhang#, Jun Xu#, Huan Zhang, Xiaoxiong Wang, Qiutong Tan, Fanglan Liu, Renwang Jiang*, Shaohui Cai*. Calotropin from Asclepias curasavica induces cell cycle arrest and apoptosis in cisplatin-resistant lung cancer cells. Biochemical and Biophysical Research Communications, 2016, 478(2): 710-715.
7. Rongrong Zhang, Haiyan Tian, Yafang Tan, Tse-Yu Chung, Xiaohui Sun, Xue Xia, Wencai Ye, David A. Middleton, Natalya Fedosova, Mikael Esmann, Jason T. C. Tzen, Renwang Jiang*. Structures, chemotaxonomic significance, cytotoxic and Na+,K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. Organic & Biomolecular Chemistry. 2014, 12(44), 8919-8929.